Anime Guardians continues to evolve with frequent balance changes and new character releases, and Update 21 has significantly shifted the meta.
With multiple Secret and Limited units added, choosing the right units and artifacts is now more important than ever.
This Anime Guardians tier list ranks the best units and artifacts in Update 21, helping you decide what to summon, upgrade, and invest in for story progression, infinite modes, and late game farming.
Anime Guardians Tier List Update 21 Overview
Last Updated: Update 21
New Units Added: 8
Based On: Damage output, utility, scaling, boss performance, farming value, and artifact synergy
Tier Meanings
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Meta: Overpowered units that dominate all content
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SSS: Extremely strong with minimal weaknesses
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SS: Strong and reliable in most game modes
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S: Good units that perform well with proper builds
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A: Decent but situational
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B: Average and replaceable
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C: Below average
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D: Not worth using
Anime Guardians Tier List – Update 21 Units
Meta Tier Units
These units currently define the endgame and perform exceptionally in every mode.
| Unit | Rarity | Why They’re Meta |
|---|---|---|
| Subaru (Greed) | Secret | Insane DPS scaling, strong artifact synergy |
| Subaru (Pride) | Secret | Burst damage with strong curse interactions |
| Regulus (Alpha Leonis) | Secret | Extremely high boss DPS and survivability |
| Reinhard (Strongest Human) | Limited | Massive raw damage and consistent performance |
SSS Tier Units
Top tier units just below Meta that excel with proper artifacts.
| Unit | Rarity | Strengths |
|---|---|---|
| Typhon (Witch of Pride) | Secret | High AoE and debuff synergy |
| Daphne (Witch of Gluttony) | Secret | Exceptional damage over time |
| Carmilla (Witch of Lust) | Secret | Strong curse and bleed scaling |
| Sekhmet (Witch of Sloth) | Secret | Defensive utility with solid DPS |
SS Tier Units
Strong picks for late game and progression.
| Unit | Rarity | Role |
|---|---|---|
| Minerva (Witch of Wrath) | Secret | Burst DPS and boss damage |
| Subaru (Gluttony) | Secret | Balanced damage and farming |
| Subaru (Envy) | Secret | Reliable mid to late game carry |
S Tier Units
Good units that perform well but are outclassed at higher stages.
| Unit Type | Notes |
|---|---|
| Sub Meta DPS units | Require good artifacts |
| Farm focused units | Efficient but weaker vs bosses |
A Tier and Below
These units are mostly useful for early to mid game or specific niches.
| Tier | General Use |
|---|---|
| A | Situational utility |
| B | Average progression |
| C | Replace as soon as possible |
| D | Not recommended |
Best Artifact Tier List – Anime Guardians Update 21
Artifacts play a huge role in maximizing unit potential. Below are the best artifacts currently dominating the meta.
Top Tier Artifacts
| Artifact | Effect |
|---|---|
| Curse Book | 2× damage boost, reduced cooldown |
| Antique Earring | +100% active skill damage |
| Netherbane Flail | Massive burn damage boost |
| Greenbone Greatsword | Bonus boss damage and cooldown reduction |
| Toxic Greatsword | Poison stacking on hit |
Strong DPS Artifacts
| Artifact | Best For |
|---|---|
| Abyssbone Scythe | Status-based units |
| Crimson Hellblade | Bleed-focused units |
| Bloody Blade | Bleed synergy |
| Emerald Necklace | Ramp-up DPS |
Utility and Support Artifacts
| Artifact | Purpose |
|---|---|
| Celestial Tear Pendant | Cooldown reduction |
| Hellmaw Shield | Tanky units |
| Emerald Whisper | Balanced DPS and cooldown |
| Sanctus Aegis | Skill-based units |
Best Team Compositions (Update 21)
Late Game DPS Team
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Subaru (Greed)
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Regulus
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Reinhard
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Support Unit with Curse Book
Farming Team
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High AoE unit
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Farm-specialized unit
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Cooldown-based support
Support Essentials
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Curse applicators
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Cooldown reducers
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Bleed or burn enablers
SEE ALSO:
- Anime Guardians Codes
- Rogue Piece Tier List – Best Spec, Fruit, & Sword (Updated)
- Reign Piece Tier List Roblox – Best Specs, Fruits, & Races
Final Thoughts
Anime Guardians Update 21 has heavily favored curse, bleed, and burn-based damage, making Secret units and artifact synergy more important than ever. If you are aiming for late-game dominance, investing in Meta and SSS tier units with optimal artifacts will give you the biggest advantage.
Keep in mind that tier lists can change with balance updates, so always adapt your team based on new releases and patches.
Which units are you currently using in Anime Guardians?
Abhigyan identifies himself as a tech geek, gaming cognoscenti, and also a connoisseur of music. Unidentified and mysterious phenomena never fail to gather his undivided attention. When not reading about bizarre and perplexing entities across the Universe, he can often be found cheering for his favorite teams in Football.